Cathepsin D targeted by acid sphingomyelinase-derived ceramide
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چکیده
منابع مشابه
Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway
The chemotherapeutic agent cisplatin is widely used in treatment of solid tumors. In breast cancer cells, cisplatin produces early and marked changes in cell morphology and the actin cytoskeleton. These changes manifest as loss of lamellipodia/filopodia and appearance of membrane ruffles. Furthermore, cisplatin induces dephosphorylation of the actin-binding protein ezrin, and its relocation fro...
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Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of cells, where it serves both as a building block for cell architecture and as a precursor of bioactive sphingolipids. In particular, upregulation of (C-type) sphingomyelinases w...
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BACKGROUND Increased pulmonary ceramide levels are suggested to play a causative role in lung diseases including COPD. Neutral sphingomyelinase-2 (nSMase-2) and acid SMase (aSMase), which hydrolyze sphingomyelin to produce ceramide, are activated by a range of cellular stresses, including inflammatory cytokines and pathogens, but notably cigarette smoke appears to only activate nSMase-2. Our pr...
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slice images of Gd-DTPA, Gd-DOTACAT and 10% BSA at 37oC at 9.4T. Figure 2. Relaxation rate (R1 = 1/T1) as a function of concentration. Gd-DOTACAT has a greater relaxivity 6.9 (mM s) than clinically used Gd-DTPA (Magnevist®) of 3.2 (mM s). Figure 3. Signal intensity plots from 3 regions of interest: brain tissue, cerebral and non-cerebral blood vessels. There was an increase in signal intensity ...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1999
ISSN: 1460-2075
DOI: 10.1093/emboj/18.19.5252